I have had many people ask what kind of testing could be done to diagnose KLS. The following information has been gathered to help you get testing that could help with a diagnosis. The following is for information purposes only as I am not a doctor and this is not medical advice.
The medical paper titled: KLS Medical Report Dynamic fMRI…has valuable diagnostic information. Your physician may be able to use the medical paper to order the tests suggested in helping with a diagnosis. This medical paper could possibly be what a doctor needs in order to be justified in ordering the tests to be completed.
Print out the Medical Paper Titled: KLS Medical Report Dynamic fMRI…and ask your physician to perform these four tests both while symptomatic and asymptomatic: MRI Brain with and without contrast, MR Perfusion, Functional MRI with MD, MR Spectroscopy. These tests have been performed on other KLS patients around the world. And the KLS patients have had similar results: Altered brain function while sick, hypoperfusion (loss of blood to the brain) while sick, and altered metabolites while sick.
The medical paper I have attached, states these tests could be used to diagnose KLS: “…would be a valuable diagnostic tool demonstrating dynamic, organic brain dysfunction consistent with the physiological basis for the behavioral and cognitive dysfunction in this disorder”.
Also, the references section of the paper has more references to the same testing done on other KLS patients.
 Engstrom M, Vigren P, Karlsson T, Landtblom AM. Working memory in 8
Kleine–Levin syndrome patients: an fMRI study. Sleep 2009;32(5):681–8.
 Hong SB, Joo EY, Tae WS, Lee J, Han SJ, Lee HW. Episodic diencephalic
hypoperfusion in Kleine–Levin syndrome. Sleep 2006;29(8):1091–3.
 Huang YS, Guilleminault C, Kao PF, Liu FY. SPECT findings in the Kleine–Levin
syndrome. Sleep 2005;28(8):955–60.
 Poryazova R, Schnepf B, Boesiger P, Bassetti CL. Magnetic resonance
spectroscopy in a patient with Kleine–Levin syndrome. J Neurol 2007;254:
 Keogh BP, Cordes D. Quantitative approaches to functional MRI: applications in
epilepsy. Epilepsia 2007;48S(4):27–36.
That right there may be enough for a medical doctor to be able to order the tests for your loved one. Once correctly diagnosed, your healing journey can begin.
Print the medical paper out and highlight the part I have quoted above. I really hope this helps you get the correct testing and diagnosis. Getting a correct diagnosis is half the battle. Please let me know the outcome of your request.